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After a single instillation is determined by the moisture front of the camera within a few hours. In carcinogenicity studies in rats study period ; 73 — 110 weeks and mice study period ; 62 — 88 weeks at doses up to 1.

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In ophthalmology eye drops. Application of pregnancy and breastfeeding Teratogenic effects of teratogenicity studies conducted in rats and mice at doses of 0. Comparative study in rodents using high doses of aspirin showed similar effects in females and their fetuses. However, reproductive studies in animals do not always predict effects in humans.

Adequate and well-controlled studies in pregnant women have not done. Vascular system of the fetus premature closure of the ductus arteriosus, the use should be avoided during pregnancy especially in the later stages. At a dose of 2. Category effects on the fetus by FDA ; C. Indomethacin passes into breast milk, so breast-feeding should be discontinued during treatment and avoid the use of indomethacin during breastfeeding.

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Side effects of substance Indomethacin Systemic side effects From the nervous system and sensory organs: From the cardio — vascular system and blood blood, hemostasis: From the digestive tract: With the genitourinary system: When where to the skin: With instillation of the eye: Interaction Reduces the diuretic effect of potassium-sparing, thiazide and loop diuretics. Sharing with paracetamol increases the risk of nephrotoxicity manifestations. Ethanol, colchicine, Indomethacin and corticotropin increase the order of bleeding in the gastrointestinal tract. Cyclosporine and gold preparations increase the nephrotoxicity due to suppression of PG synthesis in the kidneys.

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With prolonged use of the maximum daily dose should not exceed 75 mg. Upon reaching the effect of treatment should be continued for 4 weeks in the same or a reduced dose. In other testimony ; 1 drop of 3 — 4 times a day. In patients with cardio — vascular disease or risk factors for heart development. During the period of treatment must be careful when driving and occupation of other potentially hazardous activities that require high concentration and psychomotor speed reactions.

  • Either way, augmenting the dosage raises the chance of side consequences.
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